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While pulmonary EnGL loss contributes to lung injury via promotion of lung oedema and neutrophil adhesion, it was found that HPSE-mediated glomerular HS degradation could induce an early loss of glomerular filtration in the absence of kidney oedema or inflammation [51]

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It has also been proved that RS can decrease the postprandial blood glucose, increase the insulin sensitivity and improve the metabolic disorder of glucose and lipid in type 2 diabetic patients (42)