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So when you had estrogen plus MPA, you had a barely statistically significant, the P value was 0.05, so it just hit statistical significance, one in a thousand cases for breast cancer, and then you had one in a thousand cases, but P value of 0.07 for reduction of risk of breast cancer, which to me suggests that the MPA, the synthetic progesterone, was playing more of a role than anything else

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Selective estrogen receptor modulators: Tissue specificity and clinical utility