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Deficiency of substrate L-Arg and accumulation of ADMA L-Arg is the substrate for eNOS and the main precursor of NO, therefore, the availability of L-Arg is important for the activity of this enzyme, and the substrate insufficiency may lead to eNOS uncoupling (Fig
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10.3892/ijo.2015.2831 23 ChunhuaM.LongH.ZhuW.LiuZ.JieR.ZhangY.et al (2017)
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