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A number of animal groups, including primates, lack ascorbate biosynthesis capacity due to loss of function mutations in the biosynthetic enzyme L-gulono-1,4-lactone oxidase [1] but according to genome sequence analysis biosynthesis capacity may be lacking in other protist groups [2]

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These effects include a twofold increase in severe illness (diarrhea or pneumonia) in young calves [9] and up to a 1.5-month delay in the onset of estrus [10]