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More than a leaky gut: how gut priming shapes arthritis | Nature Reviews Rheumatology
438 Notably, two cytokines involved in the mt-ISR, FGF-21 and GDF-15, have shown exceptional diagnostic value for mitochondrial myopathy and tRNA gene mutation-related mitochondrial diseases, and they may also serve as biomarkers for monitoring therapeutic efficacy
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Additionally, the mRNA, protein levels and catalytic activity of CSE, which is a crucial enzyme responsible for homocysteine trans-sulfuration, were reduced due to hyperhomocysteinemia
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