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APAP hepatotoxicity is the most frequent cause of acute liver failure (ALF) in the US [1] and a recent study evaluating outcomes in adults with acute liver failure between 1998 and 2013 indicates that hepatotoxicity due to APAP accounted for almost half the cases of ALF for the entire 16-year period, with unintentional APAP overdoses, (those in which patients took excessive medication over several days for ailments like pain or fever) being more common than intentional (suicidal) overdoses [2]