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In contrast, although the proportion of γH2AX-positive cells increased for both HCT116 ΔGSTA4 (1.67 ± 2.42%) and HCT116 cells (3.69 ± 6.00%) after treatment with oxaliplatin for 48 h compared with untreated controls, no significant difference in the proportion of γH2AX-positive cells was seen between HCT116 ΔGSTA4 and HCT116 cells ( Supplementary Figures 3A, B , P = 0.618), indicating that the inactivation of GSTA4 has limited effect on low-dose oxaliplatin-induced crosslinking of DNA
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Liposomes, also known as artificial biomembranes, have good biocompatibility and promising applications, but they might encounter stability issues, and some liposomes might also provoke immune responses in the body
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