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On the other hand, as a natural antagonist of Dectin-1 receptor, laminarin can specifically bind to the highly expressed Dectin-1 receptor on the surface of microglia and inhibit the activation of the downstream Syk/NF-κB inflammatory signaling pathway, thereby blocking the polarization of microglia to the pro-inflammatory M1 phenotype

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CVD is a major cause of morbidity and mortality in these patients as they demonstrate dyslipidemia, hypertension, and atherosclerosis at a very early age [168]