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It takes indirect actions in stimulating the cellular antioxidant defense system, increasing mRNA and glutathione reductase (GSH) levels, and the activities of several antioxidant enzymes, such as glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD), which catalyzes the conversion of O 2 into H 2 O 2 [1,3,12,13,14,15,16,17,18,19,20,21]
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There is also increasing evidence that deregulation of GSH synthesis contributes to the pathogenesis of diseases such as diabetes mellitus, pulmonary and hepatic fibrosis, alcoholic liver disease, cholestatic liver injury, endotoxemia, and drug-resistant tumors cells [10]
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