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And typically when we're talking about angiogenesis in the context of tissue rejuvenation and repair, we're talking about the addition of new capillaries and or blood vessels

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Although the exact mechanism of how signaling kinases, such as MAPK, PKC, and PI3K, regulate the gene expression of GCLC and GCLM remains unclear, it is generally thought that these kinases act through direct phosphorylation of Nrf2, or other proteins involved in Nrf2-EpRE complex formation