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Consisting primarily of microvascular endothelial cells with intercellular tight junction complexes, the BNB expresses a variety of influx and efflux transporters, including solute, macromolecular, nutrient and drug transporters, immunoglobulin transporters, and ionic channels, to mention a few, forming an effective diffusion barrier and active regulator of peripheral nerve homeostasis (Figure 2b) 39–42 43

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