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2020 May;189:77-87

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For research groups, that means keeping a few boundaries clear: Use FOXO4-DRI only within approved research settings and documented protocols Describe findings as preclinical unless human data directly support a stronger claim Avoid presenting senescent-cell clearance in animal models as proof of clinical benefit Separate sourcing quality, mechanistic plausibility, and translational relevance as distinct questions Handle all communications with the same precision used in the bench work A good analogy is early-stage target validation in oncology