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Some side effects of levodopa have been reported, including sleep, psychological disturbances, and gastrointestinal adverse events such as nausea and vomiting
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Additionally, the overall quality of evidence for each outcome was evaluated using the GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) framework (Guyatt et al., 2008) which considers factors such as risk of bias, inconsistency, indirectness, imprecision, and publication bias to provide a comprehensive evaluation of the strength of evidence
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