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As an electrophilic chemical, ITCs might react covalently with the thiol groups of (proteins and) glutathione in plants, similar to what has been demonstrated in different in vitro systems 38,77,78 as well as in insects feeding on GSL or ITC diets 79,80
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The three receptors Retatrutide targets are: GLP-1 (Glucagon-Like Peptide-1) Receptors control appetite signaling in the brain and slow gastric emptying
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