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Vitamin B12 deficiency is primarily caused by autoimmune pernicious anemia, dietary restrictions such as vegetarian or vegan diets, and medical conditions that interfere with absorption such as celiac and Crohn’s disease

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References Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity, Nature Emerging opportunities for nicotinamide N-methyltransferase (NNMT) inhibitor clinical translation, Trends in Pharmacological Sciences Roles of Nicotinamide N-Methyltransferase in Obesity and Type 2 Diabetes, BioMed Research International Novel tricyclic small molecule inhibitors of Nicotinamide N-methyltransferase for the treatment of metabolic disorders, Scientific Reports Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice, Scientific Reports Nicotinamide-N-methyltransferase inhibition improves cardiac function and structure in a heart failure model, Pharmacological Research Identification of nicotinamide N-methyltransferase as a promising therapeutic target for sarcopenia, Aging Cell ER stress-induced upregulation of NNMT contributes to alcohol-related fatty liver development, Journal of Hepatology Clinical Pharmacokinetics of Oral Semaglutide: Analyses of Data from Clinical Pharmacology Trials, Clinical Pharmacokinetics ClinicalTrials.gov registry, searched for 5-amino-1MQ, 5-amino-1-methylquinolinium and NNMT inhibitor on August 25, 2026, zero studies returned openFDA Drug Label and Drug Adverse Event APIs, queried for 5-amino-1MQ on August 25, 2026, no label and no reports returned