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Under oxidative stress, H 2 O 2 catalyzes the formation of disulfide bonds between Cys57 and Cys86 on GPx7, prompts the transformation of GPx7 from reduced to oxidized form, and then oxidized GPx7 triggers the formation of disulfide bonds between Cys41 and Cys420 on GRP78, or between Cys53 and Cys56 on PDI, enhancing their activity [16]
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