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They concluded that antibiotic treatment can alter gut resistome and microbiome composition in a specific, reproducible and predictable manner and that enrichment of ABR genes and shifts in microbiome composition returned to baseline levels 90 days after antibiotic treatment cessation 6
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These properties make GDC a novel and ideal candidate for transiently inducing a leaky, infant-like epithelial phenotype, a previously unexplored approach for modeling early-life gut barrier function in vitro
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