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On the MLL-10 trial conducted by the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG), infants with KMT2A rearrangements were treated with an intensified chemotherapy backbone that included multiple phases using high-dose methotrexate, cyclophosphamide, etoposide, and high-dose cytarabine
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These findings provide both a mechanistic rationale and experimental evidence supporting the potential incorporation of AOF into modern therapeutic frameworks
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