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Cis-aconityl linkers are formed by conjugating cis-aconitic acid with amines to create acid-sensitive amide bonds, releasing payloads via acid-catalyzed hydrolysis
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A dose-related leucopenia was observed in both male and female rats and lymphoid depletion in the B-cells of the spleen was observed in both the 200- and 600-mg/kg groups at 60 days
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