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LEfSe is known to reduce false positives and can highlight biological consistency across subclasses, while the Kruskal–Wallis test used alone can achieve a lower false-negative rate compared to LEfSe 38

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In this double-blind trial of 1,961 adults with a body mass index (BMI) of 30 or higher, adults on high dose 2.4 mg of weekly semaglutide (compared with the usual type 2 diabetes dose of 0.5mg or 1mg) lost an average 14.9% of baseline body weight after 68 weeks of treatment versus only 2.4% for a group on placebo and lifestyle intervention alone