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A scheme integrating all MTX-modulated metabolites into a single metabolic panel can be found in Supplementary Figure 4
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In the pivotal Phase 1/2 clinical trial, 56 patients received venetoclax in one of eight dose groups ranging from 150 to 1200 mg per day.55 In an expansion cohort, an additional 60 patients received venetoclax with progressive weekly dose escalation up to 400 mg per day
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