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The interplay between hydrogen-producing fermentative bacteria and hydrogen consuming reductive acetogens, methanogenic archaea and sulfate-reducing bacteria becomes imbalanced in association with many gut disorders, such as inflammatory bowel disease (IBD), small intestinal bacterial overgrowth (SIBO), irritable bowel syndrome (IBS), and colon cancer ( 2 , produced by hydrogenogenic microbes, is severely depleted in deuterium, relative to the levels of deuterium in the molecules from which it was extracted