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Researchers commonly investigate these peptides in studies involving cellular signaling, tissue response mechanisms, angiogenesis pathways, and regenerative biology
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However, their expression is often highly upregulated in many solid tumors, and the sustained presence of these proteases (which can be produced by activated stromal cells, infiltrating innate immune cells and cancer cells in the tumor microenvironment), coupled with increased ECM synthesis and secretion, leads to the progressive destruction of normal ECM and its replacement by tumor-derived ECM
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